With an electric mixer, beat yogurt, eggs, sugar, vanilla and oil until combined.
Switch to a spatula and fold in flour mixture until incorporated.
Coat a 9 x 5 loaf pan with floured baking spray (or use parchment paper coated with baking spray as well) and pour in batter. Smooth evenly. Bake in a preheated oven at 350 degrees for 40-50 minutes or until a cake tester comes out clean.
Allow cake to cool at least an hour.
When cake is cool, move to a serving plate or cake platter. Mix powdered sugar with orange juice until smooth and drizzle the glaze over cake.